What is the note on the 5th fret of the 2nd string?

The note on the 5th fret of the 2nd string is E. This is because the second string of a standard-tuned guitar is tuned to B. When you move up the fretboard, each fret represents a half-step increase in pitch.

Starting from the open B note on the 2nd string, moving up to the 1st fret gives you C, the 2nd fret gives you C#, the 3rd fret gives you D, the 4th fret gives you D#, and finally, the 5th fret produces E. This systematic progression of half steps makes it easy to identify notes on the fretboard. Understanding this concept is essential for navigating the guitar and playing in different keys.