What note can be played on the 12th fret of the 1st string?

The 12th fret of the 1st string, which is also known as the high E string, corresponds to the note E. This is based on the standard tuning of a guitar, where the 1st string is tuned to E in the open position. The 12th fret represents one octave higher than the open string.

When you press down on the 12th fret, you are playing the same note as the open 1st string, but an octave higher. This understanding of how frets correspond to musical notes is essential for navigating the fretboard and understanding how to play scales and melodies across different octaves.